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A Recipe for You!

OLD-FASHIONED DEEP CHOCOLATE LAYER CAKE
Servings: 1 servings

1 3/4 cup all purpose flour, sifted
-coarsely, chopped
3/4 cup unsweetened cocoa powder
1/2 cup plus 3 tablespoons, unsalted
1 tsp baking soda
-butter, cut into small
1/4 tsp salt
-pieces
2 large eggs
4 cup powdered sugar (about 1
2 cup sugar
-pound)
1/2 cup ( 1 stick) butter, unsalted
1 tbl unsweetened cocoa powder
-cut into 4 pieces, room
-pinch of salt
-temperature
1 tbl plus
2 tsp vanilla extract

Directions: have a piece of this cake with a cold glass of milk, and you 're a kid all over again. cake position rack in center of oven and preheat to 350''f. butter three 9-inch diameter cake pans with 1 1/2-inch-high sides. line pan bottoms with parchment or waxed paper. butter paper. dust pans with flour; tap out excess. for cake: insert steel knife. place flour, cocoa, baking soda and salt in work bowl. process to "sift," about 5 seconds. transfer contents of work bowl to large sheet of waxed paper. place eggs, then sugar into work bowl. process until mixture is thick, about 1 minute. add butter and vanilla. process until mixture is fluffy, stopping to scrape down sides of work bowl, about 1 minute. mix dry ingredients into egg mixture alternately with buttermilk in about 3 additions each, pulsing just to combine each addition. divide batter evenly among prepared pans (about 1% cups in each). bake until tester inserted in center of cakes comes out clean, about 24 minutes. cool cakes in pans on racks 10 minutes. run small sharp knife around pan sides to loosen cakes. turn out onto rack. peel off paper. cool. for frosting: melt chocolate and butter in heavy small saucepan over low heat, stirring until smooth. (or to microwave: place chocolate and butter in 4-cup microwave-safe bowl. cook uncovered on high 1 minute. stir well. cook on high until almost melted, about 30 seconds longer. stir until chocolate mixture is smooth.) steel knife: place powdered sugar, cocoa and salt in work bowl. process to "sift," about 5 seconds. add chocolate mixture and vanilla. process until just combined, about 5 seconds. add 4 tablespoons sour cream. process to blend, about 8 seconds. scrape down sides of work bowl. thin to spreadable consistency by adding enough remaining sour cream by tablespoons, processing to blend after each addition. place 1 cake layer on serving platter. spread with 3/4 cup frosting. top with second cake layer. spread with 3/4 cup frosting. top with third cake layer. spread remaining frosting over top and sides of cake. (can be prepared i day ahead. refrigerate until frosting is firm, then cover and keep refrigerated. bring to room temperature before serving.) 12 servings from the files of al rice, north pole alaska. feb 1994

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THE CANCER PILL

Dr. Brian Druker of Oregon Health Sciences University was searching for a compound that could block the enzyme that caused chronic myelogenous leukemia or CML for short. He recently stabilized a compound he had noticed to suppress the enzyme, that compound, STI 571, was recently being run through clinical trials to verify its action. He has been working at Oregon Health Sciences University on the pill, but the distribution and trials of the drugs are being run through Novartis Pharmaceuticals. The outcome of this revolutionary cancer treatment could help many people currently suffering from this condition if its trials prove it completely safe. So far in the clinical trials it has had a one hundred percent success rate curing thirty-one out of thirty-one patients so far tested. The Leukemia Society of America, the National Cancer Institute, Novartis Pharmaceuticals, and the Oregon Cancer Center fund Dr. Druker’s research and studies. So far the research has only been tested on CML leukemia, but there is doubt it will work on other forms because it was specifically formulated for the suppression of the enzyme responsible for CML leukemia and its specific chromosome, the Philadelphia chromosome. Out of all the forms of leukemia CML accounts for about 1/7 of the cases only affecting about one to two people per one hundred thousand, most above the age of 50. It causes an enormous increase in the white blood cell count, sometimes as great as twelve fold or from the average 10,000 to 120,000. In most cases you die about one to three years after diagnosis.




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